Senior Scientist, Clinical PBPK Modeling
Introduction to role:
Are you ready to dive into the world of pharmacokinetics and translational modeling? As a Senior Scientist in Clinical PBPK Modeling, you'll be at the forefront of implementing innovative and quantitative approaches to propel clinical drug development. Your role will involve conducting mechanistic PBPK using clinical data to support the advancement of drug candidates across various therapy areas. You'll also have the chance to contribute to broader areas within Clinical Pharmacology & Quantitative Pharmacology (CPQP), guided by your experience, interests, and expertise. Are you excited to make a difference?
Accountabilities:
• Apply physiologically-based pharmacokinetic (PBPK) and translational modeling tools to enable clinical PK projections for drug-drug interactions (DDIs), pediatric and specific populations, and other clinical development questions.
• Collaborate with Drug Metabolism and Pharmacokinetic (DMPK) Scientists and Clinical Pharmacology scientists to generate these mechanistic models.
• Validate the mechanistic models to the level of being able to be used in Regulatory submissions and to influence the design of clinical trials.
• Communicate clearly and effectively both internally and externally on topics related to PBPK clinical DDI and pediatric and other specific populations predictions.
• Keep up to date with emerging literature, modeling science, and regulatory expectations.
Essential Skills/Experience:
• Knowledge of pharmacokinetics and Model-Informed Drug Development (MIDD).
• Demonstrated broad translational development expertise and experience exemplified by 0-4 Years of drug development experience, with emphasis on PBPK modelling.
• Good knowledge in pharmacology, drug targets and core disease areas.
• Demonstrated ability to identify, develop and implement PBPK activities at a project level.
• Good oral and written communication skills.
• Good knowledge of global regulatory, compliance, processes, standards and issues specific to PBPK.
• PhD degree preferred or equivalent (M.Sc./Pharm.D.) with relevant experience required.
• Relevant regulatory experience (written).
• Training and experience with PBPK and other relevant software (e.g., SimCYP, GastroPlus, PK-Sim, Phoenix WinNonlin).
• Fluency in spoken and written English language.
Desirable Skills/Experience:
• A reputation gained from scientific publishing in the field of DMPK/Clinical Pharmacology.
• Experience in early and late stage drug development.
When we put unexpected teams in the same room, we ignite bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and bold world.
At AstraZeneca, curiosity drives us to explore what science can achieve. We are committed to making a difference by treating, preventing, modifying, and even curing some of the world's most complex diseases. Our passion for science is fused with data and technology to achieve breakthroughs that redefine possibilities. We celebrate successes and learn from failures as we push boundaries to deliver life-changing medicines. With a diverse team united by shared values, we demonstrate global knowledge to create swift impacts on disease. Here, lifelong learning is encouraged, offering opportunities for growth in an environment where exploration thrives.
Ready to make an impact? Apply now and join us on this exciting journey!
Date Posted
25-Jun-2025Closing Date
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
]]>AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.
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